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Pfizer is seeking authorization to start distributing its covid-19 vaccine by Christmas

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Pfizer will apply for emergency permission to distribute its covid-19 vaccine in the US and is ready to start shipping the shots within “hours” of getting a government green light, the firm said today. It is the first such application from any of the makers of covid-19 vaccines that are currently in development.

If it is approved, the first people to get the shot are likely to be doctors, nurses, and other front-line workers, and that could happen before Christmas, according to the drug giant. Pfizer is also sharing information with regulators in Canada, the European Union, and Japan.

In a statement, Pfizer’s CEO, Albert Bourla, said the vaccine’s development took “248 long days and nights,” involving 43,661 volunteers at 150 locations in the US, Turkey, and South Africa. Pfizer claims its vaccine has proved to be 95% effective in its final trials.

Pfizer and its partner, German firm BioNtech, believe they can produce about 50 million doses by January, and as many as 1.3 billion doses by the end of 2021. Each recipient needs two doses, spaced weeks apart. “The companies will be ready to distribute the vaccine within hours after authorization,” Pfizer said.

While Pfizer’s vaccine may be the first to win authorization in the US, vaccine organizations say shots from several other companies will still be needed. That’s because no one company, or technology, can meet global demand for vaccination.

Other vaccines include one being developed by Moderna Pharmaceuticals, based in Massachusetts; another from AstraZeneca and Oxford University that’s in late-stage testing; and vaccines already authorized in China and in Russia.

The development of a vaccine for a new disease in less than a year has shattered all records, yet it won’t come soon enough to intercept the current winter wave of covid-19 cases in the US and Europe, where infections have reached an all-time high. The US alone is recording more than 170,000 coronavirus cases per day. If undetected infections are accounted for, that could mean half a million Americans are catching the coronavirus every 24 hours.

Because vaccines supplies will be limited at first, most people will have to wait until the middle of 2021, or beyond, to get vaccinated with the Pfizer shot or one from another company. That means for now, avoiding the virus still means avoiding other people. This week, the US Centers for Disease Control began discouraging Americans from traveling for the Thanksgiving holiday next Thursday.

Pfizer’s request to market its vaccines now means it is up to the Food and Drug Administration whether to issue a type of fast-track approval called an “emergency-use authorization.” A committee of advisors will meet in December to assess Pfizer’s data documenting how well the shots worked.

Some experts still question whether a vaccine should be rushed out, saying a formal, somewhat longer approval process would create more confidence in the product among the general public.

Since March, the FDA has used it emergency authorization power to allow the sale of four medical treatments for covid-19 (hydroxychloroquine, donor blood plasma, the antiviral remdesivir, and an antibody), each time on the basis of limited evidence. In every case, it remains disputed whether any of those drugs actually prevent patients from dying.

The Pfizer vaccine employs a novel technology in which part of the virus’s genome is packaged inside fatty nanoparticles. A person’s own cells then use that information to manufacture a single viral protein, called a “spike,” which trains the immune system to recognize the pathogen.

Pfizer said that it is able to manufacture and distribute its vaccine from several locations in the US and Europe and will use special ultra-cold shipping boxes tracked by GPS devices, since its product needs to be kept at a temperature of -70 °C.

Lyron Foster is a Hawaii based African American Musician, Author, Actor, Blogger, Filmmaker, Philanthropist and Multinational Serial Tech Entrepreneur.

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This is the most precise 3D map of the Milky Way ever made

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Data collected by the European Space Agency’s Gaia observatory has been used to create the most detailed 3D map of the galaxy ever made. The new data set could help scientists unravel many mysteries about the universe’s expansion and the solar system’s future.

What is Gaia? Launched in 2013, the Gaia observatory is intended to observe as many of the galaxy’s stars as possible. It is designed to measure stellar positions, distances, motions, and brightness with more precision than any instrument before, with the goal of cataloguing approximately 1 billion objects. It is designed to observe each object about 70 times or so in order to track their motions and velocities over time, accurate enough to measure the width of a hair from 2,000 kilometers away.

The new map: The latest data pinpoints the location and movements of just under 2 billion stars, with highly accurate measurements of about 300,000 stars within 326 light-years of the solar system. The new map shows us that our solar system’s orbit around the Milky Way is accelerating by seven millimeters every year, bringing it that much closer to the center of the Milky Way over time. 

What could we learn? The point of the mission isn’t simply to get a glimpse of the galaxy’s stars in motion. The data could help astronomers answer a number of different scientific questions, including how the Milky Way was formed over time, where the solar system and other star systems are headed, what the expansion of the universe looks like, and the distribution of regular and dark matter throughout the galaxy. Previous Gaia data sets have been used to ascertain the mass of the Milky Way and how many sun-like stars might be orbited by Earth-light planets.

What’s next: Gaia will be operational until about 2022, but it’s holding up better than expected and could see its mission extend to 2024 or beyond. The final data release should catalogue more than 2 billion objects in the galaxy.

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YouTube introduces new features to address toxic comments

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YouTube today announced it’s launching a new feature that will push commenters to reconsider their hateful and offensive remarks before posting. It will also begin testing a filter that allows creators to avoid having to read some of the hurtful comments on their channel that had been automatically held for review. The new features are meant to address long standing issues with the quality of comments on YouTube’s platform — a problem creators have complained about for years.

The company said it will also soon run a survey aimed at giving equal opportunity to creators, and whose data can help the company to better understand how some creators are more disproportionately impacted by online hate and harassment.

The new commenting feature, rolling out today, is a significant change for YouTube.

The feature appears when users are about to post something offensive in a video’s comments section and warns to “Keep comments respectful.” The message also tells users to check the site’s Community Guidelines if they’re not sure if a comment is appropriate.

The pop-up then nudges users to click the “Edit” button and revise their comment by making “Edit” the more prominent choice on the screen that appears.

The feature will not actually prevent a user from posting their comment, however. If they want to proceed, they can click the “Post Anyway” option instead.

Image Credits: YouTube

The idea to put up roadblocks to give users time to pause and reconsider their words and actions is something several social media platforms are now doing.

For instance, Instagram last year launched a feature that would flag offensive comments before they were posted. It later expanded that to include offensive captions. Without providing data, the company claimed that these “nudges” were helping to reduce online bullying. Meanwhile, Twitter this year began to push users to read the article linked in tweets they were about to share before tweeting their reaction, and it stopped users from being able to retweet with just one click.

These intentional pauses built into the social platforms are designed to stop people from reacting to content with heightened emotion and anger, and instead push users to be more thoughtful in what they say and do. User interface changes like this leverage basic human psychology to work, and may even prove effective in some percentage of cases. But platforms have been hesitant to roll out such tweaks as they can stifle user engagement.

In YouTube’s case, the company tells TechCrunch its systems will learn what’s considered offensive based on what content gets repeatedly flagged by users. Over time, the system should be able to improve as the technology gets better at detection and the system itself is further developed.

Users on Android in the English language will see the new prompts first, starting today, Google says. The rollout will complete over the next couple of days. The company did not offer a timeframe for the feature’s support for other platforms and languages or even a firm commitment that such support would arrive in the future.

In addition, YouTube said it will also now begin testing a feature for creators who use YouTube Studio to manage their channel.

Creators will be able to try out a new filter that will hide the offensive and hurtful comments that have automatically been held for review.

Today, YouTube Studio users can choose to auto-moderate potentially inappropriate comments, which they can then manually review and choose to approve, hide or report. While it’s helpful to have these held, it’s still often difficult for creators to have to deal with these comments at all, as online trolls can be unbelievably cruel. With the filter, creators can avoid these potentially offensive comments entirely.

YouTube says it will also streamline its moderation tools to make the review process easier going forward.

The changes follow a year during which YouTube has been heavily criticized for not doing enough to combat hate speech and misinformation on its platform. The video platform’s “strikes” system for rule violations means that videos may be individually removed but a channel itself can stay online unless it collects enough strikes to be taken down. In practice, that means a YouTube creator could be as violent as calling for government officials to be beheaded and and still continue to use YouTube. (By comparison, that same threat led to an account ban on Twitter.)

YouTube claims it has increased the number of daily hate speech comment removals by 46x since early 2019. And in the last quarter, of the more than 1.8 million channels it terminated for violating our policies, more than 54,000 terminations were for hate speech. That indicates a growing problem with online discourse that likely influenced these new measures. Some would argue the platforms have a responsibility to do even more, but it’s a difficult balance.

In a separate move, YouTube said it’s soon introducing a new survey that will ask creators to voluntarily share with YouTube information about their gender, sexual orientation, race and ethnicity. Using the data collected, YouTube claims it will be able to better examine how content from different communities is treated in search, discovery and monetization systems.

It will also look for possible patterns of hate, harassment, and discrimination that could affect some communities more than others, the company explains. And the survey will give creators to optionally participate in other initiatives that YouTube hosts, like #YouTubeBlack creator gatherings or FanFest, for instance.

This survey will begin in 2021 and was designed in consultation with input from creators and civil and human rights experts. YouTube says the collected data will not be used for advertising purposes, and creators will have the ability to opt-out and delete their information entirely at any time.

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Google’s co-lead of Ethical AI team says she was fired for sending an email

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Timnit Gebru, a leading researcher and voice in the field of ethics and artificial intelligence, says Google fired her for an email she sent to her direct reports.  According to Gebru, Google fired her because of an email she sent to subordinates that the company said reflected “behavior that is inconsistent with the expectations of a Google manager.”

Gebru, the co-leader of Google Ethical Artificial Intelligence team, took to Twitter last night, shortly after the National Labor Relations Board filed a complaint against Google alleging surveillance of employees and unlawful firing of employees.

Gebru says no one explicitly told her she was fired, but that she received an email from one of her boss’s reports, saying:

“Thanks for making your conditions clear. We cannot agree to #1 and #2 as you are requesting. We respect your decision to leave Google as a result, and we are accepting your resignation.”

That email, according to Gebru, went on to say that “certain aspects of the email you sent last night to non-management employees in the brain group reflect behavior that is inconsistent with the expectations of a Google manager.”

It’s not clear what exactly was contained in the email. We’ve reached out to both Gebru and Google for comment.

As Bloomberg reported, Gebru has been outspoken about the lack of diversity in tech as well as the injustices Black people in tech face. According to Bloomberg, Gebru believes Google let her go to signal to other workers that it’s not ok to speak up.

Gebru is a leading voice in the field of ethics and artificial intelligence. In 2018, Gebru collaborated with Joy Buolamwini, founder of the Algorithmic Justice League, to study biases in facial recognition systems. They found high disparities in error rates between lighter males and darker females, which led to the conclusion that those systems didn’t work well for people with darker skin.

Since Gebru’s announcement, she’s received an outpouring of support from those in the tech community.

Developing…

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